Kartogenin

• CAT Number: I003636
• CAS Number: 4727-31-5
• Molecular Formula: C20H15NO3
• Molecular Weight: 317.30
• Purity: ≥95%
• Synonyms: 2-[(4-phenylphenyl)carbamoyl]benzoic acid
• Target: TGF-beta/Smad
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: Store at +4C
• IC50: 100 nM(EC50, promotes chondrocyte differentiation)
• InChI: InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
• InChIKey: SLUINPGXGFUMLL-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3C(=O)O

Kartogenin（Cat No.:I003636）is a small molecule that has gained attention for its potential therapeutic effects in cartilage repair and regeneration. It promotes the differentiation of mesenchymal stem cells into chondrocytes, the cells responsible for producing cartilage, making it a promising candidate for treating osteoarthritis and other cartilage-related disorders. Kartogenin works by activating the Nrf2 pathway, which regulates antioxidant and anti-inflammatory responses, thereby protecting cartilage from damage. Preclinical studies have shown that kartogenin can stimulate cartilage repair and reduce inflammation, offering hope for developing non-invasive treatments for joint degeneration.