Kasugamycin hydrochloride hydrate

• CAT Number: I002536
• CAS Number: 200132-83-8
• Molecular Formula: C14H28ClN3O10
• Molecular Weight: 433.84
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-amino-2-[(2R,3S,5S,6R)-5-amino-2-methyl-6-[(2S,3S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]iminoacetic acid;hydrate;hydrochloride
• InChI: InChI=1S/C14H25N3O9.ClH.H2O/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H;1H2/t3-,4+,5+,6?,7+,8+,9-,10+,11?,14-;;/m1../s1
• InChIKey: URDOPMVCASNBEZ-VHRLMMNYSA-N
• SMILES: C[C@@H]1[C@H](C[C@@H]([C@H](O1)OC2[C@@H]([C@H](C([C@@H]([C@@H]2O)O)O)O)O)N)N=C(C(=O)O)N.O.Cl

Kasugamycin Hydrochloride Hydrate（Cat No.:I002536）is an aminoglycoside antibiotic originally derived from Streptomyces kasugaensis, primarily used in agriculture to control bacterial and fungal diseases in crops, like rice blast. It works by inhibiting protein synthesis through selective binding to the 30S ribosomal subunit, thereby preventing the initiation of translation in susceptible pathogens. Due to its unique mechanism, Kasugamycin has minimal impact on beneficial soil microbes and is less likely to induce widespread resistance. It is also explored in laboratory settings for studies on translation mechanisms and antibiotic resistance.

Reference

[1]. Chenchen Zhu, et al. Identification and engineering of regulation-related genes toward improved kasugamycin production. Appl Microbiol Biotechnol, DOI 10.1007/s00253-015-7082-3
[2]. Yoshii A, et al. Two types of genetic carrier, the IncP genomic island and the novel IncP-1β plasmid, for the aac(2/’)-IIa gene that confers kasugamycin resistance in Acidovorax avenae ssp. avenae. Mol Plant Pathol. 2015 Apr;16(3):288-300.