KAT modulator-1

• CAT Number: I040792
• CAS Number: 1314006-43-3
• Molecular Formula: C20H36O2
• Molecular Weight: 308.50
• Purity: ≥95%
• Synonyms: 3-pentadecylidenepentane-2,4-dione
• InChI: InChI=1S/C20H36O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(18(2)21)19(3)22/h17H,4-16H2,1-3H3
• InChIKey: IHNCRYVYEGKPQM-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCC=C(C(=O)C)C(=O)C

KAT modulator-1 (Compound 3) is a KAT modulator. KAT modulator-1 can interact with p300 full-length but not with the catalytic domain. KAT modulator-1 can be used for epigenetics research[1].
KAT modulator-1 (Compound 3) (50 μM) inhibits recombinant acetyltransferase enzymes KAT3A by 79-83%[1].
KAT modulator-1 (15 and 30 μM) reduces H3 acetylation in histone extracts of U937 leukemia cells[1].

Reference

[1]. Milite C, et al. Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs). Bioorg Med Chem. 2011 Jun 15;19(12):3690-701.
 [Content Brief]