Kathon Biocide

• CAT Number: M004429
• CAS Number: 55965-84-9
• Molecular Formula: C8H9ClN2O2S2
• Molecular Weight: 264.74
• Purity: ≥95%
• Synonyms: 5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone;Kathon 886;kathon biocide;CMIT/MIT B/PLUS;Con WT;CMI/MI Kathon 886;2-Methylisothiazol-3(2H)-one 5-chloro-2-Methylisothiazol-3(2H)-one (1:1);2-Methylisothiazol-3(2H)-one coMpound
• Storage: -20°C
• IUPAC Name: 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
• InChI: InChI=1S/C4H4ClNOS.C4H5NOS/c1-6-4(7)2-3(5)8-6;1-5-4(6)2-3-7-5/h2H,1H3;2-3H,1H3
• InChIKey: QYYMDNHUJFIDDQ-UHFFFAOYSA-N
• SMILES: CN1C(=O)C=CS1.CN1C(=O)C=C(S1)Cl

Kathon Biocide（Cat No.:M004429）, is a chemical compound used as a broad-spectrum preservative and antimicrobial agent in various industrial and consumer products. It is effective against bacteria, fungi, and other microorganisms, making it valuable in formulations such as personal care products (shampoos, lotions), paints, adhesives, and cooling water systems. Kathon Biocide prevents the growth of harmful microorganisms, thereby extending the shelf life of products and reducing the risk of contamination.

Reference

1: Cardin CW, Weaver JE, Bailey PT. Dose-response assessments of Kathon biocide. (II). Threshold prophetic patch testing. Contact Dermatitis. 1986 Jul;15(1):10-6. PubMed PMID: 3757497.
2: Chan PK, Baldwin RC, Parsons RD, Moss JN, Stiratelli R, Smith JM, Hayes AW. Kathon biocide: manifestation of delayed contact dermatitis in guinea pigs is dependent on the concentration for induction and challenge. J Invest Dermatol. 1983 Nov;81(5):409-11. PubMed PMID: 6631051.
3: Weaver JE, Cardin CW, Maibach HI. Dose-response assessments of Kathon biocide (I). Diagnostic use and diagnostic threshold patch testing with sensitized humans. Contact Dermatitis. 1985 Mar;12(3):141-5. PubMed PMID: 3995942.
4: deBethizy JD, Longacre SL, Steigerwalt RB, Deckert FW, Moss JN, Hayes AW, Smith JM, Scribner HE. Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to male Sprague-Dawley rats. Food Chem Toxicol. 1986 Jan;24(1):43-9. PubMed PMID: 3949268.
5: Moss JN. Reconciling clinical data with risk: the Kathon biocide story. Occup Med. 1994 Jan-Mar;9(1):113-9. PubMed PMID: 8016697.
6: Scribner HE, McCarthy KL, Moss JN, Hayes AW, Smith JM, Cifone MA, Probst GS, Valencia R. The genetic toxicology of Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one. Mutat Res. 1983 Aug;118(3):129-52. PubMed PMID: 6410231.