kb-NB77-78

• CAT Number: I001347
• CAS Number: 1350622-33-1
• Molecular Formula: C18H25NO3Si
• Molecular Weight: 331.5
• Purity: ≥95%
• Synonyms: 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-b]pyridin-5-one
• Solubility: 10 mM in DMSO
• Storage: -20°C
• InChIKey: UNMWMPXUIXEQJZ-UHFFFAOYSA-N

KB-NB77-78 (Cat.No:I001347) is a novel small-molecule inhibitor that targets the bromodomain and extra-terminal domain (BET) proteins. It has demonstrated potent anti-proliferative activity in preclinical studies, inhibiting cancer cell growth and inducing cell cycle arrest. Further research is being conducted to evaluate its potential as a therapeutic agent for various types of cancer.

Reference

[1]. George KM, et al. Design, Synthesis, and Biological Evaluation of PKD Inhibitors. Pharmaceutics. 2011;3(2):186-228.