For research use only. Not for therapeutic Use.
KB-R7943 mesylate（Cat No.:I002362） is a potent and selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger. With an IC50 value of 0.7 mM, it effectively inhibits the activity of the Na+/Ca2+ exchanger in this mode. By blocking the reverse mode of the Na+/Ca2+ exchanger, KB-R7943 mesylate disrupts the regulation of intracellular calcium levels, which has implications for various physiological and pathological processes. This compound serves as a valuable tool for studying the role of the Na+/Ca2+ exchanger and its potential as a therapeutic target in calcium-related disorders.
| Catalog Number | I002362 |
| CAS Number | 182004-65-5 |
| Synonyms | methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate |
| Molecular Formula | C16H17N3O3S • CH3SO3H |
| Purity | ≥95% |
| Target | Na+/Ca2+ Exchanger |
| Solubility | H2O: ≤ 4.3 mg/mL (Need warming) |
| Storage | 2-8°C |
| IC50 | 0.7 mM |
| IUPAC Name | methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate |
| InChI | InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) |
| InChIKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-] |
| Reference | <p style=/line-height:25px/> |
