KBU2046

• CAT Number: I018153
• CAS Number: 1143863-69-7
• Molecular Formula: C₁₅H₁₁FO₂
• Molecular Weight: 242.25
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease

KBU2046 (CAT: I018153) is a remarkable oral compound recognized for its high selectivity in inhibiting cell motility and cell invasion in vitro. Unlike conventional HSP90 inhibitors, KBU2046 binds to chaperone heterocomplexes and selectively modulates the interaction of client proteins that regulate cellular motility. This unique mechanism of action distinguishes KBU2046 from classical HSP90 inhibitors. Notably, KBU2046 has demonstrated efficacy in inhibiting cancer metastasis and extending life in preclinical studies.

Reference

[1]. Xu L, et al. Precision therapeutic targeting of human cancer cell motility. Nat Commun. 2018 Jun 22;9(1):2454.