KC 3791

• CAT Number: I030013
• CAS Number: 85793-29-9
• Molecular Formula: C23H29N3O
• Molecular Weight: 395.503
• Purity: 98%
• Synonyms: KC 3791; KC-3791; KC3791
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(3-(Diethylamino)-2-hydroxypropyl)-3-methoxy-1-phenyl-1H-indole-2-carboxamide
• InChI: InChI=1S/C23H29N3O3/c1-4-25(5-2)16-18(27)15-24-23(28)21-22(29-3)19-13-9-10-14-20(19)26(21)17-11-7-6-8-12-17/h6-14,18,27H,4-5,15-16H2,1-3H3,(H,24,28)
• InChIKey: JZQYAVBXJCQSOK-UHFFFAOYSA-N
• SMILES: O=C(C(N1C2=CC=CC=C2)=C(OC)C3=C1C=CC=C3)NCC(O)CN(CC)CC

KC 3791 (Cat No.: I030013) is an experimental compound studied for its potential antihyperlipidemic and antidiabetic properties. It functions primarily as a peroxisome proliferator-activated receptor (PPAR) agonist, influencing lipid metabolism and insulin sensitivity. In preclinical models, KC 3791 has demonstrated the ability to lower plasma triglycerides and improve glucose homeostasis, suggesting potential therapeutic applications in metabolic disorders such as type 2 diabetes and dyslipidemia. Although not clinically approved, KC 3791 remains a useful research tool for exploring PPAR-mediated metabolic regulation and drug development.

Reference

1: Zaborovskaya LD, Khodorov BI. Effects of KC 3791 on sodium and potassium channels in frog node of Ranvier. Gen Physiol Biophys. 1986 Dec;5(6):605-15. PMID: 2435614.
2: Khodorov BI, Zaborovskaya LD. Use-dependent blockade of sodium channels by local anaesthetics and antiarrhythmic drugs. Effects of chloramine-T and calcium ions. Drugs Exp Clin Res. 1986;12(9-10):743-52. PMID: 2431852.
3: Zaborovskaya LD, Khodorov BI. The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrythmics. Gen Physiol Biophys. 1984 Dec;3(6):517-20. PMID: 6099302.