For research use only. Not for therapeutic Use.
RA-2 is a potent and selective KCa2/3 pan inhibitor with negative-gating modulator properties (IC50 values of 17 and 2 nM for KCa3.1 and KCa2.3, respectively). RA-2 inhibited EDH-type dilations in porcine coronary arteries (PCAs) and was found not to increase blood pressure in telemetry recordings despite reducing heart rate (HR).
KEYWORDS: KCa modulator RA-2 | KCa2/3 inhibitor | KCa modulator RA2 | KCa modulator RA 2 | CAS [1867107-62-7] | Potassium | KCa3.1 | KCa2 | Opener | Ion Channels | Hypotension | Hyperemia | Chronic inflammation
| Catalog Number | I014661 |
| CAS Number | 1867107-62-7 |
| Molecular Formula | C22H16F2O6 |
| Purity | ≥95% |
| IUPAC Name | [3-[(3-fluoro-4-hydroxybenzoyl)oxymethyl]phenyl]methyl 3-fluoro-4-hydroxybenzoate |
| InChI | InChI=1S/C22H16F2O6/c23-17-9-15(4-6-19(17)25)21(27)29-11-13-2-1-3-14(8-13)12-30-22(28)16-5-7-20(26)18(24)10-16/h1-10,25-26H,11-12H2 |
| SMILES | C1=CC(=CC(=C1)COC(=O)C2=CC(=C(C=C2)O)F)COC(=O)C3=CC(=C(C=C3)O)F |
| Reference | A Oliván-Viguera et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015 Feb;87(2):338-48. |
