KDM2/7-IN-1

• CAT Number: R064171
• CAS Number: 1453071-47-0
• Molecular Formula: C15H27NO4
• Molecular Weight: 285.38
• Purity: ≥95%
• Synonyms: 3-[9-cyclopropylnonanoyl(hydroxy)amino]propanoic acid
• InChI: InChI=1S/C15H27NO4/c17-14(16(20)12-11-15(18)19)8-6-4-2-1-3-5-7-13-9-10-13/h13,20H,1-12H2,(H,18,19)
• InChIKey: NEHSERYKENINRH-UHFFFAOYSA-N
• SMILES: C1CC1CCCCCCCCC(=O)N(CCC(=O)O)O

KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

Reference

[1]. Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31.
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