KDM4C-IN-1

• CAT Number: I043567
• CAS Number: 52348-60-4
• Molecular Formula: C14H13N5O3
• Molecular Weight: 299.28
• Purity: ≥95%
• Synonyms: 3-(4-methoxyphenyl)-1,6-dimethylpyrido[3,4-e][1,2,4]triazine-5,7-dione
• InChI: InChI=1S/C15H14N4O3/c1-18-12(20)8-11-13(15(18)21)16-14(17-19(11)2)9-4-6-10(22-3)7-5-9/h4-8H,1-3H3
• InChIKey: LAPJIJPJZVGVNW-UHFFFAOYSA-N
• SMILES: CN1C2=CC(=O)N(C(=O)C2=NC(=N1)C3=CC=C(C=C3)OC)C

KDM4C-IN-1 (Compound 4d) is a potent KDM4C inhibitor with an IC50 of 8 nM. KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells with IC50s of 0.8 µM and 1.1 µM, respectively[1].

Reference

[1]. Vatroslav Letfus, et al. Rational design, synthesis and biological profiling of new KDM4C inhibitors. Bioorg Med Chem. 2020 Jan 1;28(1):115128.
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