KDM4D-IN-1

• CAT Number: I013216
• CAS Number: 2098902-68-0
• Molecular Formula: C₁₁H₇N₅O
• Molecular Weight: 225.21
• Purity: ≥95%
• Target: Histone Demethylase
• Solubility: DMSO: 6 mg/mL (Need ultrasonic)
• IUPAC Name: 4-methyl-8-oxo-2,3,7,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,10,12-pentaene-5-carbonitrile
• InChI: InChI=1S/C11H7N5O/c1-6-8(5-12)10-14-11(17)7-3-2-4-13-9(7)16(10)15-6/h2-4,15H,1H3
• InChIKey: ACTIHECDWUUJPX-UHFFFAOYSA-N
• SMILES: CC1=C(C2=NC(=O)C3=C(N2N1)N=CC=C3)C#N

KDM4D-IN-1(CAT: I013216) is a potent and selective inhibitor of lysine demethylase 4D (KDM4D), an epigenetic enzyme responsible for the demethylation of histone H3 lysine 9 (H3K9me3/me2) and histone H3 lysine 36 (H3K36me3/me2). By inhibiting KDM4D, this compound alters chromatin structure and gene expression, impacting processes such as cell proliferation, DNA repair, and transcriptional regulation. KDM4D-IN-1 is valuable in epigenetics research and is being explored for its therapeutic potential in oncology, particularly for cancers where abnormal histone methylation contributes to tumor progression and drug resistance.