For research use only. Not for therapeutic Use.
KDM5-C49 (Cat No.: I030022) is a selective inhibitor of KDM5 (JARID1) histone demethylases, which regulate gene expression by removing methyl groups from histone H3K4. By inhibiting KDM5 activity, KDM5-C49 affects chromatin remodeling and transcriptional regulation, making it a valuable tool in epigenetic and cancer research. It has been studied for its potential to counteract drug resistance in cancer by modulating gene expression patterns. KDM5-C49 is particularly relevant in targeting cancers with dysregulated histone methylation, offering promise for novel therapeutic strategies.
| CAS Number | 1596348-16-1 |
| Synonyms | KDM5-C49; KDM5 C49; KDM5C49; |
| Molecular Formula | C15H24N4O3 |
| Purity | 98% |
| Target | Histone Demethylase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-{[(2-{[2-(Dimethylamino)ethyl](ethyl)amino}-2-oxoethyl)amino]methyl}isonicotinic Acid |
| InChI | InChI=1S/C15H24N4O3/c1-4-19(8-7-18(2)3)14(20)11-16-10-13-9-12(15(21)22)5-6-17-13/h5-6,9,16H,4,7-8,10-11H2,1-3H3,(H,21,22) |
| InChIKey | RGGMVQDDHDCRDM-UHFFFAOYSA-N |
| SMILES | O=C(O)C1=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C1 |
| Reference | 1: Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. doi: 10.1038/nchembio.2087. Epub 2016 May 23. PubMed PMID: 27214403. |
