KDM5-IN-1

• CAT Number: I013680
• CAS Number: 1628210-26-3
• Molecular Formula: C₁₇H₂₀N₆O
• Molecular Weight: 324.38
• Purity: ≥95%
• Target: Histone Demethylase
• Solubility: DMSO: ≥ 30 mg/mL
• IUPAC Name: 5-(1-tert-butylpyrazol-4-yl)-7-oxo-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
• InChI: InChI=1S/C17H20N6O/c1-10(2)13-14(12-8-19-22(9-12)17(3,4)5)21-15-11(6-18)7-20-23(15)16(13)24/h7-10,20H,1-5H3
• InChIKey: YQCOPPONWZNBQO-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(N=C2C(=CNN2C1=O)C#N)C3=CN(N=C3)C(C)(C)C

KDM5-IN-1 (Cat.No:I013680) is a potent and selective inhibitor of lysine-specific demethylase 5 (KDM5) enzymes. It acts by targeting the catalytic domain of KDM5 enzymes, leading to the inhibition of histone demethylation and gene expression modulation. This compound shows potential for therapeutic applications in cancer and other diseases associated with abnormal histone methylation patterns.

Reference

[1]. Liang J, et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41.