For research use only. Not for therapeutic Use.
KDU691（Cat No.:I014421）is a selective inhibitor of phosphoinositide 3-kinase delta (PI3Kδ), a key enzyme in the PI3K/Akt signaling pathway that plays a critical role in immune cell function, particularly in B-cells and T-cells. By blocking PI3Kδ, KDU691 disrupts signaling processes involved in cell survival, proliferation, and immune responses, making it a valuable compound for studying immune-related disorders and cancers, especially hematological malignancies. It has shown promise in preclinical models of cancer, where it inhibits tumor growth and modulates immune system activity, making it a potential candidate for targeted therapies.
| Catalog Number | I014421 |
| CAS Number | 1513879-19-0 |
| Synonyms | KDU691; KDU-691; KDU 691;;N-(4-chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide |
| Molecular Formula | C22H18ClN5O2 |
| Purity | ≥95% |
| Target | PI4K; Parasite |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide |
| InChI | InChI=1S/C22H18ClN5O2/c1-24-21(29)15-5-3-14(4-6-15)19-11-26-20-12-25-18(13-28(19)20)22(30)27(2)17-9-7-16(23)8-10-17/h3-13H,1-2H3,(H,24,29) |
| InChIKey | TYMFFISSODJRDV-UHFFFAOYSA-N |
| SMILES | CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl |
| Reference | </br>1: Orjuela-Sanchez P, Villa ZH, Moreno M, Tong-Rios C, Meister S, LaMonte GM,</br> Campo B, Vinetz JM, Winzeler EA. Developing Plasmodium vivax Resources for Liver </br> Stage Study in the Peruvian Amazon Region. ACS Infect Dis. 2018 Apr</br> 13;4(4):531-540. doi: 10.1021/acsinfecdis.7b00198. Epub 2018 Mar 15. PubMed PMID:</br> 29542317.</br>2: Dembele L, Ang X, Chavchich M, Bonamy GMC, Selva JJ, Lim MY, Bodenreider C,</br> Yeung BKS, Nosten F, Russell BM, Edstein MD, Straimer J, Fidock DA, Diagana TT,</br> Bifani P. The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits</br> dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Sci</br> Rep. 2017 May 24;7(1):2325. doi: 10.1038/s41598-017-02440-6. PubMed PMID:</br> 28539634; PubMed Central PMCID: PMC5443816.</br>3: Zeeman AM, Lakshminarayana SB, van der Werff N, Klooster EJ, Voorberg-van der </br> Wel A, Kondreddi RR, Bodenreider C, Simon O, Sauerwein R, Yeung BK, Diagana TT,</br> Kocken CH. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in</br> Plasmodium vivax-Type Malaria Parasites. Antimicrob Agents Chemother. 2016 Apr</br> 22;60(5):2858-63. doi: 10.1128/AAC.03080-15. Print 2016 May. PubMed PMID:</br> 26926645; PubMed Central PMCID: PMC4862498.</br> </br> |
