KEA1-97

• CAT Number: I030030
• CAS Number: 2138882-71-8
• Molecular Formula: C15H9Cl2FN4
• Molecular Weight: 335.16
• Purity: 98%
• Synonyms: KEA1-97; KEA1 97; KEA197
• Target: Caspase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4,6-dichloro-N-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine
• InChI: InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)
• InChIKey: DUROVTLUQOYUPH-UHFFFAOYSA-N
• SMILES: ClC1=NC(Cl)=NC(NC2=CC=C(C3=CC=C(F)C=C3)C=C2)=N1

KEA1-97(CAT: I030030) is a compound that disrupts the interaction between thioredoxin and caspase 3. This disruption leads to the activation of caspases and the induction of apoptosis, a programmed cell death process. Importantly, KEA1-97 has shown efficacy in impairing breast cancer pathogenicity, suggesting its potential as an anti-cancer agent. Additionally, KEA1-97 has demonstrated the ability to inhibit the growth of breast tumor xenografts in vivo. These findings highlight the potential therapeutic implications of KEA1-97 in breast cancer treatment.

Reference

1: Anderson KE, To M, Olzmann JA, Nomura DK. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13. PubMed PMID: 28892616.