Ketanserin tartrate

• CAT Number: I005020
• CAS Number: 83846-83-7
• Molecular Formula: C22H22FN3O3 • C4H6O6
• Molecular Weight: 545.52
• Purity: ≥95%
• Synonyms: R 49945
• Target: 0.11 μM (hERG current)[1]
• Solubility: H2O: ≤ 30 mg/mL (Need ultrasonic and warming)
• Storage: 2-8°C
• IUPAC Name: 2,3-dihydroxybutanedioic acid;3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
• InChI: InChI=1S/C22H22FN3O3.C4H6O6/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;5-1(3(7)8)2(6)4(9)10/h1-8,16H,9-14H2,(H,24,29);1-2,5-6H,(H,7,8)(H,9,10)
• InChIKey: KMTLTEVOQLMYRS-UHFFFAOYSA-N
• SMILES: C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O.C(C(C(=O)O)O)(C(=O)O)O

Ketanserin Tartrate（Cat No.:I005020）is a selective serotonin 5-HT2A receptor antagonist primarily used to manage hypertension and certain vascular conditions. By blocking 5-HT2A receptors, it reduces serotonin-induced vasoconstriction, thereby lowering blood pressure and improving blood flow. Ketanserin Tartrate also exhibits antagonistic activity on alpha-1 adrenergic receptors, contributing to its vasodilatory effects. It has been explored in research related to thrombosis, vasospasm, and other cardiovascular disorders. Additionally, its role in modulating serotonin pathways has made it a valuable tool in studying psychiatric and neurological conditions involving serotonin dysregulation.

Reference

[1]. Tang Q, et al. The 5-HT2 antagonist Ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. Br J Pharmacol. 2008 Oct;155(3):365-73.
[2]. Khan N, et al. Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists. Drug Des Devel Ther. 2015 Jul 6;9:3497-506.
[3]. Kekewska A, et al. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012 Feb;340(2):369-76.
[4]. Jiang DG, et al. Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Neural Regen Res. 2016 Sep;11(9):1471-1479.