For research use only. Not for therapeutic Use.
Ketoconazole (CAS 65277-42-1) is a synthetic imidazole antifungal drug used primarily to treat fungal infections. It is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff—seborrhoeic dermatitis of the scalp).
| Catalog Number | A000489 |
| CAS Number | 65277-42-1 |
| Synonyms | Xolegel; Extina; 65277-42-1; Kuric; Nizoral |
| Molecular Formula | C26H28Cl2N4O4 |
| Purity | ≥95% |
| Target | P450 |
| Solubility | >23.4mg/mL in DMSO |
| Storage | -20°C |
| Overview of Clinical Research | <span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”>Ketoconazole is a <span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>14-alpha demethylase inhibitor. It is marketed to treat </span><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Seborrhoeic dermatitis.</span></span></span> |
| IUPAC Name | 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone |
| InChI | InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 |
| InChIKey | XMAYWYJOQHXEEK-OZXSUGGESA-N |
| SMILES | CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
| Reference | 1: Viljoen JM, Botes D, Steenekamp JH. Formulation and evaluation of selected transmucosal dosage forms containing a double fixed-dose of acyclovir and ketoconazole. Eur J Pharm Sci. 2017 Nov 1;111:503-513. doi: 10.1016/j.ejps.2017.10.033. [Epub ahead of print] PubMed PMID: 29080856.<br /> |
