For research use only. Not for therapeutic Use.
(+)-Ketoconazole（Cat No.:I001619）is an optically active form of the antifungal agent ketoconazole, widely used in the treatment of fungal infections. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, disrupting membrane integrity and function. Additionally, it has applications in the treatment of conditions like Cushing’s syndrome due to its ability to inhibit cortisol synthesis. As a potent inhibitor of cytochrome P450 enzymes, (+)-Ketoconazole is also explored for its potential in drug metabolism studies and as a tool for metabolic research.
| Catalog Number | I001619 |
| CAS Number | 142128-59-4 |
| Synonyms | 1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone |
| Molecular Formula | C26H28Cl2N4O4 |
| Purity | ≥95% |
| Target | Fungal; Cytochrome P450 |
| Solubility | DMSO 3 mg/mL; Water <1 mg/mL |
| Storage | Store at -20C |
| IUPAC Name | 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone |
| InChI | InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 |
| InChIKey | XMAYWYJOQHXEEK-OZXSUGGESA-N |
| SMILES | CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl |
| Reference | <p style=/line-height:25px/> <br>[2]. Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75. </p> |
