Ketorolac

• CAT Number: I004750
• CAS Number: 74103-06-3
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.3
• Purity: ≥95%
• Synonyms: 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• Target: COX
• Solubility: DMSO 75 mg/mL; Water 75 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
• InChIKey: OZWKMVRBQXNZKK-UHFFFAOYSA-N
• SMILES: C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O

Ketorolac (Cat No.: I004750) is a non-selective inhibitor of cyclooxygenase (COX), with an IC50 of approximately 1.23 µM for human COX-1 and 3.50 µM for human COX-2. It is commonly employed as an anti-inflammatory analgesic, providing relief from pain and inflammation. Additionally, Ketorolac exhibits an anti-platelet aggregation effect, making it valuable in certain cardiovascular and thrombotic conditions. This dual action on COX enzymes and its anti-inflammatory properties contribute to its clinical utility. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Jett, M.F., et al., Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther, 1999. 288(3): p. 1288-97.

[2]. Berg, J., et al., The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res, 1999. 48(7): p. 369-79.

[3]. Chang, J.K., et al., Anti-inflammatory drugs suppress proliferation and induce apoptosis through altering expressions of cell cycle regulators and pro-apoptotic factors in cultured human osteoblasts. Toxicology, 2009. 258(2-3): p. 148-56.