Ketotifen-d3 Fumarate

• CAT Number: R058239
• CAS Number: 1795138-23-6
• Molecular Formula: C23H23NO5S
• Molecular Weight: 428.517
• Purity: ≥95%
• Synonyms: 4,9-Dihydro-4-[1-(methyl-d3)-4-piperidinylidene]-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one (2E)-2-Butenedioate; Ketotifen-d3 Hydrogen Fumarate; Totifen-d3; Zaditen-d3; Zaditor-d3; Zasten-d3
• Target: Neuronal Signaling
• Storage: -20°C
• IUPAC Name: (E)-but-2-enedioic acid;10-[1-(trideuteriomethyl)piperidin-4-ylidene]-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
• InChI: InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/i1D3
• InChIKey: YNQQEYBLVYAWNX-PCUGBSCUSA-N
• SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O

Ketotifen-d3 fumarate is a deuterium-labeled version of ketotifen fumarate, a well-known antihistamine and mast cell stabilizer used primarily to treat allergic conditions such as asthma, allergic conjunctivitis, and rhinitis. The incorporation of deuterium, a stable isotope of hydrogen, into its molecular structure enhances the metabolic stability of the drug, potentially improving its pharmacokinetic properties. This labeled variant is commonly used in drug metabolism and pharmacokinetic studies to track the absorption, distribution, and excretion of ketotifen.