Ketotifen fumarate

• CAT Number: I003263
• CAS Number: 34580-14-8
• Molecular Formula: C19H19NOS • C4H4O4
• Molecular Weight: 425.50
• Purity: ≥95%
• Synonyms: (E)-but-2-enedioic acid;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one
• Target: Histamine Receptor
• Solubility: DMSO: ＞ 36 mg/mL
• Storage: 2-8°C
• IUPAC Name: (E)-but-2-enedioic acid;2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
• InChI: InChI=1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: YNQQEYBLVYAWNX-WLHGVMLRSA-N
• SMILES: CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=C/C(=O)O)\C(=O)O

Ketotifen Fumarate（Cat No.:I003263）is an antihistamine and mast cell stabilizer commonly used to treat allergic conditions such as asthma, allergic rhinitis, and conjunctivitis. By blocking histamine H1 receptors and preventing the release of inflammatory mediators from mast cells, it helps reduce symptoms like itching, swelling, and bronchoconstriction. Ketotifen is also used as an adjunctive therapy in the prevention of asthma attacks. It is available in oral and ophthalmic formulations, providing both systemic and localized relief from allergy-related symptoms with minimal sedative effects compared to first-generation antihistamines.

Reference

[1]. Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59(9):1213-21.