For research use only. Not for therapeutic Use.
KH-4-43 is an inhibitor of E3 CRL4. KH-4-43 inhibits E3 CRL4’s core ligase complex and exhibits anticancer activity. KH-4-43 has a binding Kd to E3 ROC1-CUL4A CTD or the highly related ROC1-CUL1 CTD at 83 nM or 9.4 μM, respectively[1].
| Catalog Number | I040178 |
| CAS Number | 2813310-07-3 |
| Synonyms | 3-[1-(4-chlorophenyl)pyrazol-4-yl]-7,8-dihydroxy-2-(trifluoromethyl)chromen-4-one |
| Molecular Formula | C19H10ClF3N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H10ClF3N2O4/c20-10-1-3-11(4-2-10)25-8-9(7-24-25)14-15(27)12-5-6-13(26)16(28)17(12)29-18(14)19(21,22)23/h1-8,26,28H |
| InChIKey | KDPAGFLLKCODNF-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1N2C=C(C=N2)C3=C(OC4=C(C3=O)C=CC(=C4O)O)C(F)(F)F)Cl |
| Reference | [1]. Wu K, et al. Targeting Cullin-RING E3 Ubiquitin Ligase 4 by Small Molecule Modulators. J Cell Signal. 2021;2(3):195-205. |
