KH-CB19

• CAT Number: I001367
• CAS Number: 1354037-26-5
• Molecular Formula: C15H13Cl2N3O2
• Molecular Weight: 338.19
• Purity: ≥95%

KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM)[1][2].
KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells[1].
KH-CB19 (50 μM; 6 h) inhibits the disruption by CLK4 in A549 cells[2].

Reference

[1]. Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76.
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[2]. Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196.
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