KHK-IN-1 hydrochloride

• CAT Number: I001160
• CAS Number: 1303470-48-5
• Molecular Formula: C21H27ClN8S
• Molecular Weight: 459.01
• Purity: ≥95%
• Target: Ketohexokinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20C

KHK-IN-1 hydrochloride（Cat No.:I001160) is also known as KHK inhibitor 1 hydrochloride.KHK-IN-1 hydrochloride is a highly effective inhibitor of hexokinase (KHK) with an IC50 value of 12 nM.

Reference

[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9.
[2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.