KHK-IN-1 hydrochloride

• CAT Number: I001160
• CAS Number: 1303470-48-5
• Molecular Formula: C21H27ClN8S
• Molecular Weight: 459.01
• Purity: ≥95%
• Target: Ketohexokinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: 8-N-(cyclopropylmethyl)-4-N-(2-methylsulfanylphenyl)-2-piperazin-1-ylpyrimido[5,4-d]pyrimidine-4,8-diamine;hydrochloride
• InChI: InChI=1S/C21H26N8S.ClH/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29;/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,25)(H,26,27,28);1H
• InChIKey: VKIBPWKARAEIHN-UHFFFAOYSA-N
• SMILES: CSC1=CC=CC=C1NC2=NC(=NC3=C2N=CN=C3NCC4CC4)N5CCNCC5.Cl

KHK-IN-1 Hydrochloride(CAT: I001160) is a potent and selective inhibitor of ketohexokinase (KHK, also known as fructokinase), an enzyme involved in fructose metabolism. By targeting KHK, it reduces fructose phosphorylation and downstream metabolic processes, making it valuable in metabolic disease research. This compound is particularly relevant for studying conditions like non-alcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes, where fructose metabolism plays a critical role. KHK-IN-1 Hydrochloride is a crucial tool for exploring the therapeutic potential of KHK inhibition and advancing the development of treatments for metabolic disorders.