Kif15-IN-2

• CAT Number: I004528
• CAS Number: 672926-33-9
• Molecular Formula: C20H20N6O4S
• Molecular Weight: 440.48
• Purity: ≥95%
• Synonyms: (S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid
• Target: Kinesin
• Solubility: 10 mM in DMSO
• Storage: Store at -20C

Kif15-IN-2 is a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in tumor cell lines.IC50 value:Target: Kif15Mitotic kinesins are attractive targets for the discovery and development of novel antimitotic chemotherapeutics. Accordingly, it is an object of the present invention to provide methods, compounds, and compositions useful in the inhibition of HsKif15, a mitotic kinesin.By Mcdonald, Andrew; Bergnes, Gustave; Morgans, David J.From U.S. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.

Reference

[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.