Kif15-IN-2

• CAT Number: I004528
• CAS Number: 672926-33-9
• Molecular Formula: C20H20N6O4S
• Molecular Weight: 440.48
• Purity: ≥95%
• Synonyms: (S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid
• Target: Cytoskeleton
• Solubility: 10 mM in DMSO
• Storage: Store at -20C
• IUPAC Name: (2S)-2-(2,4-dioxo-1H-quinazolin-3-yl)-3-methyl-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]butanamide
• InChI: InChI=1S/C20H20N6O4S/c1-9(2)14(26-18(28)12-7-5-6-8-13(12)22-20(26)29)16(27)23-19-21-10(3)15(31-19)17-25-24-11(4)30-17/h5-9,14H,1-4H3,(H,22,29)(H,21,23,27)/t14-/m0/s1
• InChIKey: OHVKUJISCPKSER-AWEZNQCLSA-N
• SMILES: CC1=C(SC(=N1)NC(=O)[C@H](C(C)C)N2C(=O)C3=CC=CC=C3NC2=O)C4=NN=C(O4)C

Kif15-IN-2(CAT: I004528) is a potent and selective inhibitor of Kif15, a kinesin motor protein essential for mitotic spindle assembly and maintenance. By targeting Kif15, Kif15-IN-2 disrupts microtubule dynamics, leading to cell cycle arrest and inhibition of cell proliferation. This compound is particularly valuable in cancer research, as Kif15 plays a critical role in tumor cell division and survival, especially in cancers resistant to other mitotic inhibitors. With its high specificity and efficacy, Kif15-IN-2 is a powerful tool for studying mitotic mechanisms, advancing oncology drug discovery, and exploring novel therapeutic strategies targeting cell division.