KIF18A-IN-1

• CAT Number: I045190
• CAS Number: 2600559-12-2
• Molecular Formula: C28H40N4O5S2
• Molecular Weight: 576.77
• Purity: ≥95%
• Synonyms: 2-(6-azaspiro[2.5]octan-6-yl)-4-(tert-butylsulfamoyl)-N-[3-(tert-butylsulfamoyl)phenyl]benzamide
• InChI: InChI=1S/C28H40N4O5S2/c1-26(2,3)30-38(34,35)21-9-7-8-20(18-21)29-25(33)23-11-10-22(39(36,37)31-27(4,5)6)19-24(23)32-16-14-28(12-13-28)15-17-32/h7-11,18-19,30-31H,12-17H2,1-6H3,(H,29,33)
• InChIKey: XQJSQKALBZNWEV-UHFFFAOYSA-N
• SMILES: CC(C)(C)NS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)N3CCC4(CC4)CC3

KIF18A-IN-1 is a mitotic kinesin KIF18A inhibitor extracted from patent WO2021026098A1 example 100-13. KIF18A-IN-1 exhibits anti-tumor activity[1].

Reference

[1]. Tamayo NA, et, al. Kif18a inhibitors. WO2021026098A1.