KIF18A-IN-2

• CAT Number: I043855
• CAS Number: 2600559-20-2
• Molecular Formula: C25H34N4O5S2
• Molecular Weight: 534.69
• Purity: ≥95%
• Synonyms: 2-(6-azaspiro[2.5]octan-6-yl)-N-[3-(tert-butylsulfamoyl)phenyl]-4-(methanesulfonamido)benzamide
• InChI: InChI=1S/C25H34N4O5S2/c1-24(2,3)28-36(33,34)20-7-5-6-18(16-20)26-23(30)21-9-8-19(27-35(4,31)32)17-22(21)29-14-12-25(10-11-25)13-15-29/h5-9,16-17,27-28H,10-15H2,1-4H3,(H,26,30)
• InChIKey: BSVSZERUDCKTME-UHFFFAOYSA-N
• SMILES: CC(C)(C)NS(=O)(=O)C1=CC=CC(=C1)NC(=O)C2=C(C=C(C=C2)NS(=O)(=O)C)N3CCC4(CC4)CC3

KIF18A-IN-2（Cat No.:I043855）is a selective inhibitor targeting KIF18A, a motor protein that regulates mitotic spindle dynamics during cell division. By inhibiting KIF18A, this compound disrupts proper chromosome alignment and segregation, leading to mitotic arrest and potential cell death. KIF18A-IN-2 is particularly valuable in cancer research, as it can selectively target proliferating cancer cells and interfere with their ability to divide properly. Its ability to disrupt mitosis makes it a promising candidate for developing novel anti-cancer therapies, especially for tumors with dysregulated cell division and growth.