KIF18A-IN-3

• CAT Number: I043854
• CAS Number: 2600577-49-7
• Molecular Formula: C28H38N4O5S2
• Molecular Weight: 574.76
• Purity: ≥95%
• Synonyms: 2-(6-azaspiro[2.5]octan-6-yl)-N-[3-(tert-butylsulfamoyl)phenyl]-4-[(1-methylcyclopropyl)sulfonylamino]benzamide
• InChI: InChI=1S/C28H38N4O5S2/c1-26(2,3)31-38(34,35)22-7-5-6-20(18-22)29-25(33)23-9-8-21(30-39(36,37)27(4)10-11-27)19-24(23)32-16-14-28(12-13-28)15-17-32/h5-9,18-19,30-31H,10-17H2,1-4H3,(H,29,33)
• InChIKey: MZGYQJDGUVDYIK-UHFFFAOYSA-N
• SMILES: CC1(CC1)S(=O)(=O)NC2=CC(=C(C=C2)C(=O)NC3=CC(=CC=C3)S(=O)(=O)NC(C)(C)C)N4CCC5(CC5)CC4

KIF18A-IN-3（Cat No.:I043854）is a selective inhibitor targeting KIF18A, a motor protein involved in regulating mitotic spindle dynamics during cell division. By inhibiting KIF18A, KIF18A-IN-3 disrupts the proper alignment and segregation of chromosomes, leading to cell cycle arrest and potential apoptosis in cancer cells. This makes it a promising candidate for cancer therapy, particularly in tumors with aberrant cell division. KIF18A-IN-3 is valuable in research exploring the mechanisms of mitosis and in the development of novel treatments targeting cell division-related processes in cancer and other proliferative diseases.