KIF18A-IN-7

• CAT Number: I041405
• CAS Number: 2914878-00-3
• Molecular Formula: C27H35N3O5S2
• Molecular Weight: 545.71
• Purity: ≥95%
• InChI: InChI=1S/C27H35N3O5S2/c1-25(2,3)29-37(34,35)21-7-5-6-19(16-21)24(31)30-18-27(14-12-26(10-11-26)13-15-27)22-17-20(8-9-23(22)30)28-36(4,32)33/h5-9,16-17,28-29H,10-15,18H2,1-4H3
• InChIKey: CPAWWZCHEMFYGG-UHFFFAOYSA-N
• SMILES: CC(C)(C)NS(=O)(=O)C1=CC=CC(=C1)C(=O)N2CC3(CCC4(CC4)CC3)C5=C2C=CC(=C5)NS(=O)(=O)C

KIF18A-IN-7 (Compound 22) is an orally active KIF18A inhibitor with an IC50 of 9.4 nM against KIF18A microtubule-dependent ATPase activity[1].
KIF18A-IN-7 (Compound 22; 7 days) inhibits JIMT-1, NIH-OVCAR3 and HCC-15 cells viability with IC50s of 0.0078, 0.0097 and 0.011 μM, respectively[1].
KIF18A-IN-7 (Compound 22; 10-60 mg/kg; p.o.; twice or once a day for 1 month) inhibits HCC15 and OVCAR3 tumor growth in mice[1].

Reference

[1]. COGAN, et al. SPIRO INDOLINE INHIBITORS OF KIF18A. Patent WO2023028564.