KIN101

• CAT Number: I045990
• CAS Number: 610753-87-2
• Molecular Formula: C16H11BrO5S
• Molecular Weight: 395.22
• Purity: ≥95%
• Synonyms: [3-(4-bromophenyl)-4-oxochromen-7-yl] methanesulfonate
• InChI: InChI=1S/C16H11BrO5S/c1-23(19,20)22-12-6-7-13-15(8-12)21-9-14(16(13)18)10-2-4-11(17)5-3-10/h2-9H,1H3
• InChIKey: SJGDYHHAYHRLNC-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=C(C=C3)Br

KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses[1][2].
KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance[1].
KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels[1].
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM[1].
KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells[1].
KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5[1].
KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV)[2].

Reference

[1]. Bedard KM, et al. Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses. J Virol. 2012 Jul;86(13):7334-44.
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[2]. Shawn P. Iadonato, et al. Anti-viral compounds, pharmaceutical compositions and methods of use thereof. US20160122312A1.