KIN1400

• CAT Number: R067150
• CAS Number: 446826-86-4
• Molecular Formula: C24H17F2N3O2S
• Molecular Weight: 449.47
• Purity: ≥95%
• IUPAC Name: 7-[(1,3-benzothiazol-2-ylamino)-[4-(difluoromethoxy)phenyl]methyl]quinolin-8-ol
• InChI: InChI=1S/C24H17F2N3O2S/c25-23(26)31-16-10-7-15(8-11-16)20(29-24-28-18-5-1-2-6-19(18)32-24)17-12-9-14-4-3-13-27-21(14)22(17)30/h1-13,20,23,30H,(H,28,29)
• SMILES: C1=CC=C2C(=C1)N=C(S2)NC(C3=CC=C(C=C3)OC(F)F)C4=C(C5=C(C=CC=N5)C=C4)O

KIN1400 is an innate immune agonist of IRF3 activation to mediate broad-spectrum antiviral activity. KIN1400 is a RLR pathway agonist.
Keywords: KIN1400 | Supplier | IRF3 agonist | KIN 1400 | KIN-1400 | CAS [446826-86-4] | RLR pathway | RLR | agonist | Receptors | Innate immunity | Antiviral | RLR | Transcription factor interferon regulatory factor 3 | RIG-I-like receptor pathway

Reference

S Pattabhi et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87.