KJ Pyr 9

  • CAT Number: I004168
  • CAS Number: 581073-80-5
  • Molecular Formula: C22H15N3O4
  • Molecular Weight: 385.4
  • Purity: ≥95%
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KJ Pyr 9 (CAT: I004168) is a novel small-molecule inhibitor of MYC, a transcription factor that plays a critical role in cancer development and progression. KJ-Pyr-9 specifically targets MYC and interferes with its function both in vitro and in vivo. In vitro studies have shown that KJ-Pyr-9 inhibits MYC-induced oncogenic transformation and disrupts MYC-MAX complex formation, which is essential for MYC-mediated transcriptional regulation. KJ-Pyr-9 preferentially affects the proliferation of MYC-overexpressing cells and reduces the MYC-driven transcriptional signature. Furthermore, it inhibits apoptosis-associated cleaved caspase 3 and can dissociate the intact MYC-MAX complex.


Catalog Number I004168
CAS Number 581073-80-5
Synonyms

4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide

Molecular Formula C22H15N3O4
Purity ≥95%
Target c-Myc
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 6.5 ± 1.0 nM (Kd)
InChIKey GTTDVYCKFQYVNN-UHFFFAOYSA-N
Reference

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<br>[1]. Hart JR, et al. Inhibitor of MYC identified in a Kr?hnke pyridine library. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61.

<br>[2]. Raffeiner P, et al. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget. 2014 Oct 15;5(19):8869-78.

<br>[3]. Novel molecule hits key cancer target. Cancer Discov. 2014 Nov;4(11):OF8.

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