KJ Pyr 9 (CAT: I004168) is a novel small-molecule inhibitor of MYC, a transcription factor that plays a critical role in cancer development and progression. KJ-Pyr-9 specifically targets MYC and interferes with its function both in vitro and in vivo. In vitro studies have shown that KJ-Pyr-9 inhibits MYC-induced oncogenic transformation and disrupts MYC-MAX complex formation, which is essential for MYC-mediated transcriptional regulation. KJ-Pyr-9 preferentially affects the proliferation of MYC-overexpressing cells and reduces the MYC-driven transcriptional signature. Furthermore, it inhibits apoptosis-associated cleaved caspase 3 and can dissociate the intact MYC-MAX complex.
Catalog Number | I004168 |
CAS Number | 581073-80-5 |
Synonyms | 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide |
Molecular Formula | C22H15N3O4 |
Purity | ≥95% |
Target | c-Myc |
Solubility | 10 mM in DMSO |
Storage | Store at -20°C |
IC50 | 6.5 ± 1.0 nM (Kd) |
InChIKey | GTTDVYCKFQYVNN-UHFFFAOYSA-N |
Reference | <p style=/line-height:25px/> <br>[2]. Raffeiner P, et al. In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential. Oncotarget. 2014 Oct 15;5(19):8869-78. <br>[3]. Novel molecule hits key cancer target. Cancer Discov. 2014 Nov;4(11):OF8. </p> |