For research use only. Not for therapeutic Use.
KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].
KKII5 interacts with HIS499 of the cavity by forming one π–π stacking interaction between the phenyl ring of the molecule and the imidazole ring of HIS499[1].
KKII5 (100 μM) strongly inhibits lipid peroxidation with 98% inhibition[1].
| Catalog Number | I041246 |
| CAS Number | 6381-55-1 |
| Synonyms | 4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione |
| Molecular Formula | C16H14N2S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14N2S/c19-16-17-14(12-7-3-1-4-8-12)11-15(18-16)13-9-5-2-6-10-13/h1-11,14H,(H2,17,18,19) |
| InChIKey | HFRXOUDZIXBXEH-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3 |
| Reference | [1]. Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8(13):11966-11977. |
