KKL-10

• CAT Number: I013550
• CAS Number: 952849-76-2
• Molecular Formula: C₁₄H₁₀BrN₃O₂S
• Molecular Weight: 364.22
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide
• InChI: InChI=1S/C14H10BrN3O2S/c1-8-2-4-9(5-3-8)13-17-18-14(20-13)16-12(19)10-6-7-11(15)21-10/h2-7H,1H3,(H,16,18,19)
• InChIKey: QKSDWSBGDVYRKQ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)C2=NN=C(O2)NC(=O)C3=CC=C(S3)Br

KKL-10（Cat No.:I013550）is a novel antibacterial compound identified for its potential to inhibit bacterial growth by targeting the bacterial enzyme ClpP, a protease essential for protein homeostasis in bacteria. By disrupting ClpP activity, KKL-10 impairs bacterial stress response and survival, making it particularly effective against persistent and drug-resistant bacterial strains. This compound has shown promise in preclinical studies, especially for combating Gram-negative pathogens. KKL-10 is under investigation as a candidate for developing new antimicrobial therapies, addressing the urgent need for innovative treatments against antibiotic-resistant infections.

Reference

[1]. Goralski TD, et al. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.