KN-93 hydrochloride

• CAT Number: I002498
• CAS Number: 1956426-56-4
• Molecular Formula: C26H29ClN2O4S • HCl
• Molecular Weight: 537.5
• Purity: ≥95%
• Synonyms: (E)-N-(2-(((3-(4-chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride
• Target: CaM kinase II
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20C
• IC50: 370 nM (Ki); 12uM (NIH3T3 Cell) [1]
• InChIKey: ATHMCQDBXQEIOK-IPZCTEOASA-N

KN-93 hydrochloride (Cat.No:I002498) is a potent and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). It blocks the activity of CaMKII by preventing its association with calmodulin, a calcium-binding protein. KN-93 hydrochloride is widely used in research to investigate the role of CaMKII in cellular processes and signaling pathways.

Reference

[1]. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.
[2]. Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.
[3]. Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
[4]. Rokhlin OW, et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35.