For research use only. Not for therapeutic Use.
Inhibitor of multifunctional Ca2+/Calmodulin-dependent protein kinase (CaMKII; Ki value 0.37 μM for inhibition of CaMKII phosphorylating activity). In addition, KN93 also affects CaV1.3 and CaV1.2 calcium channels in a CaMKII-independent manner.
The water soluble phosphate salt of KN 93 (Axon 2555) is available as well.
KEYWORDS: KN 93 | supplier | CaMKII inhibitor | KN93 | CAS [1188890-40-5] | [1188890-41-6] | LCC | RyRs |PLB| CaMK | Inhibitor | calcium | channel | calmodulin | myosin | dependent | Ca2+ | CaV1.3 | CaV1.2 | Alzheimer’s | Angelman | L-type | ryanodine | phospholamban | ECC | arrhythmia
| Catalog Number | I047615 |
| CAS Number | 1188890-40-5 |
| Molecular Formula | C26H29ClN2O4S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide |
| InChI | InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+ |
| SMILES | CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC |
| Reference | M Sumi et al. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75.
ME Anderson et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.
L Gao et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10. |
