For research use only. Not for therapeutic Use.
KN2 is a bivalent CK2 inhibitor. KN2 binds to CK2 with low nanomolar affinity, is cell-permeable, and suppresses the intracellular phosphorylation of typical CK2 substrates. Kinase profiling revealed a high selectivity of KN2 for CK2 and emphasizes the selectivity-promoting potential of the αD pocket.
| Catalog Number | I030116 |
| Synonyms | KN2; KN 2; KN-2; |
| Molecular Formula | C23H22Br4Cl2N4O2 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | N1-(3,4-dichlorophenethyl)-N4-(4-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-1-yl)butyl)succinamide |
| InChI | InChI=1S/C23H22Br4Cl2N4O2/c24-18-19(25)21(27)23-22(20(18)26)32-12-33(23)10-2-1-8-30-16(34)5-6-17(35)31-9-7-13-3-4-14(28)15(29)11-13/h3-4,11-12H,1-2,5-10H2,(H,30,34)(H,31,35) |
| InChIKey | HHGOOXRIHBVNFX-UHFFFAOYSA-N |
| SMILES | O=C(NCCC1=CC=C(Cl)C(Cl)=C1)CCC(NCCCCN2C=NC3=C(Br)C(Br)=C(Br)C(Br)=C23)=O |
| Reference | 1: Lindenblatt D, Applegate V, Nickelsen A, Klußmann M, Neundorf I, Götz C, Jose J, Niefind K. Molecular Plasticity of Crystalline CK2α’ Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J Med Chem. 2021 Jul 29. doi: 10.1021/acs.jmedchem.1c00063. Epub ahead of print. PMID: 34323071. |
