Kobe0065

• CAT Number: I003549
• CAS Number: 436133-68-5
• Molecular Formula: C15H11ClF3N5O4S
• Molecular Weight: 449.79
• Purity: ≥95%
• Synonyms: N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide
• Target: Ras
• Solubility: DMSO: ≥ 42.5 mg/mL
• Storage: Store at -20C
• IC50: 46 uM (Ki) [1]
• IUPAC Name: 1-(3-chloro-4-methylphenyl)-3-[2,6-dinitro-4-(trifluoromethyl)anilino]thiourea
• InChI: InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
• InChIKey: KSJVAYBCXSURMQ-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl

Kobe0065（Cat No.:I003549）is a small molecule inhibitor that targets the Ras signaling pathway, specifically designed to disrupt the interaction between Ras and its downstream effector, Raf. Ras proteins play a critical role in cell proliferation, survival, and differentiation, and their mutations are implicated in various cancers. By inhibiting the Ras-Raf interaction, Kobe0065 interferes with oncogenic Ras signaling, making it a promising compound for cancer research. Its selective inhibition of this pathway offers potential therapeutic applications in targeting Ras-driven tumors and understanding Ras-mediated cellular processes.

Reference

[1]. Shima, Fumi, et al. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America (2013), 110(20), 8182-8187, S8182/1-S8182/10.