Kongensin A

• CAT Number: R003586
• CAS Number: 885315-96-8
• Molecular Formula: C22H30O5
• Molecular Weight: 374.47
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: [(2R,4R,8R,9S,13R)-2-hydroxy-5,5,9-trimethyl-14-methylidene-10,15-dioxo-8-tricyclo[11.2.1.04,9]hexadec-1(16)-enyl] acetate
• InChI: InChI=1S/C22H30O5/c1-12-14-6-7-18(25)22(5)17(11-16(24)15(10-14)20(12)26)21(3,4)9-8-19(22)27-13(2)23/h10,14,16-17,19,24H,1,6-9,11H2,2-5H3/t14-,16-,17-,19-,22-/m1/s1
• InChIKey: NUUWPMNNBHROPI-ASAQZKIWSA-N
• SMILES: CC(=O)O[C@@H]1CCC([C@@H]2[C@@]1(C(=O)CC[C@@H]3C=C([C@@H](C2)O)C(=O)C3=C)C)(C)C

Kongensin A（Cat No.:R003586）is a natural product derived from Croton kongensis, known for its potent inhibition of VCP/p97, an essential ATPase involved in protein homeostasis and degradation pathways. By targeting VCP/p97, Kongensin A disrupts processes like the unfolded protein response, autophagy, and endoplasmic reticulum-associated degradation (ERAD), leading to the accumulation of misfolded proteins and inducing apoptosis in cancer cells. It has gained significant attention in oncology research for its potential to selectively target cancer cells with dysregulated protein homeostasis. Kongensin A is a valuable tool for exploring novel cancer treatment strategies.