For research use only. Not for therapeutic Use.
KOTX1 is a selective, non-cytotoxic and reversible ALDH1A3 inhibitor with a cellular IC50 value of 5.1 nM. KOTX1 improved glucose control, increased insulin secretion, and enhanced glucose tolerance.
Keywords: KOTX1 | Supplier | ALDH1A3 inhibitor | KOTX 1 | KOTX-1 | CAS [1788963-83-6] | Alcohol | ALDH | Inhibitor | Enzymes | β-cell failure | Type 2 diabetes | β-cell dedifferentiation | RALDH3
| Catalog Number | I047706 |
| CAS Number | 1788963-83-6 |
| Molecular Formula | C17H16FN3O2 |
| Purity | ≥95% |
| IUPAC Name | 3-ethyl-N-(7-fluoro-2-oxo-3,4-dihydro-1H-quinolin-6-yl)pyridine-4-carboxamide |
| InChI | InChI=1S/C17H16FN3O2/c1-2-10-9-19-6-5-12(10)17(23)21-15-7-11-3-4-16(22)20-14(11)8-13(15)18/h5-9H,2-4H2,1H3,(H,20,22)(H,21,23) |
| SMILES | CCC1=C(C=CN=C1)C(=O)NC2=C(C=C3C(=C2)CCC(=O)N3)F |
| Reference | J Son et al. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023 Feb 2;14(1):558. |
