KPT-276

For research use only. Not for therapeutic Use.

  • CAT Number: I030144
  • CAS Number: 1421919-75-6
  • Molecular Formula: C16H10F8N4O
  • Molecular Weight: 426.26
  • Purity: ≥95%
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PKT-276(CAT: I030144) is an oral bioavailable, selective inhibitor of nuclear export (SINE) and a potent CRM1 antagonist. By irreversibly binding to CRM1, a key protein involved in the export of cargo proteins from the nucleus, PKT-276 disrupts the normal cellular trafficking of several important regulatory proteins. This inhibition leads to the accumulation of tumor suppressor proteins in the nucleus, triggering cell cycle arrest and apoptosis in cancer cells. PKT-276 is being investigated in Cancer Disease Research for its potential to enhance the efficacy of chemotherapy and overcome resistance mechanisms, making it a promising therapeutic agent in cancer treatment.


CAS Number 1421919-75-6
Synonyms

(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one

Molecular Formula C16H10F8N4O
Purity ≥95%
IUPAC Name (Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-1-(3,3-difluoroazetidin-1-yl)prop-2-en-1-one
InChI InChI=1S/C16H10F8N4O/c17-14(18)6-27(7-14)12(29)1-2-28-8-25-13(26-28)9-3-10(15(19,20)21)5-11(4-9)16(22,23)24/h1-5,8H,6-7H2/b2-1-
InChIKey JCHAWRDHMUSLMM-UPHRSURJSA-N
SMILES C1C(CN1C(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)(F)F

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