For research use only. Not for therapeutic Use.
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects[1][2].
KR-32568 (10 nM-1 μM) inhibits NHE-1-mediated platelet swelling induced by intracellular acidifi cation of rabbit platelet-rich plasma in a concentration-dependent manner, with the IC50 value of 24 nM[1].
KR-32568 (0.1-1.0 mg/kg; i.v.; once) exert potent cardioprotective effects in rats, such as reduces infarct size, and significantly reduces the total number of ventricular premature beats[1].
| Catalog Number | I042332 |
| CAS Number | 852146-73-7 |
| Synonyms | N-(diaminomethylidene)-5-(5-fluoro-2-methylphenyl)furan-2-carboxamide |
| Molecular Formula | C13H12FN3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18) |
| InChIKey | DTLDHYBZLVASJQ-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)F)C2=CC=C(O2)C(=O)N=C(N)N |
| Reference | [1]. Hui-Yul Roh, et al. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. [2]. Sunkyung Lee, et al. (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. |
