KR-33494

• CAT Number: I011867
• CAS Number: 1021497-97-1
• Molecular Formula: C20H18BrN3O3S
• Molecular Weight: 460.34
• Purity: ≥95%
• Synonyms: 4-[[2-[(4-bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
• Target: TNF Receptor
• Storage: -20°C
• IUPAC Name: 4-[[2-(4-bromophenyl)sulfanylacetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylic acid
• InChI: InChI=1S/C20H18BrN3O3S/c21-15-6-8-16(9-7-15)28-13-18(25)22-17-12-24(23-19(17)20(26)27)11-10-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2,(H,22,25)(H,26,27)
• InChIKey: ZRLJEHIUGYTTSZ-UHFFFAOYSA-N
• SMILES: BrC1=CC=C(SCC(NC2=CN(CCC3=CC=CC=C3)N=C2C(O)=O)=O)C=C1

KR-33494 (CAT: I011867) is a compound that serves as a fluorescent-tagged and biotin-tagged probe for Fas-associated factor 1 (FAF1). FAF1 is a protein involved in Fas-mediated cell death, which is a process of programmed cell death (apoptosis) triggered by the binding of the Fas ligand to the Fas receptor. The use of KR-33494 as a probe allows for the visualization and detection of FAF1 and its interactions within cellular processes related to Fas-mediated cell death. This type of probe can be valuable in studying the mechanisms and regulation of apoptosis and potentially aid in the development of therapeutic strategies targeting Fas signaling pathways.