KS-176

• CAT Number: I001008
• CAS Number: 1253452-78-6
• Molecular Formula: C₂₂H₁₉N₃O₅
• Molecular Weight: 405.4
• Purity: ≥95%
• Synonyms: N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
• Target: BCRP
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: Store at +4C
• IC50: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).
• InChI: InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27)
• InChIKey: LTWQQWSXYYXVGA-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)CCO)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-]

KS-176 (CAT: I001008) is a potent and selective inhibitor of the breast cancer resistance protein (BCRP), which is a multidrug transporter involved in drug efflux from cells. BCRP plays a crucial role in drug resistance by pumping various anticancer drugs out of cancer cells, leading to reduced effectiveness of chemotherapy. KS-176’s inhibitory action on BCRP can potentially enhance the intracellular concentration of chemotherapeutic agents, thereby overcoming drug resistance and improving the therapeutic outcomes of anticancer treatments.

Reference

[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505.