KS370G

• CAT Number: M137062
• CAS Number: 105955-01-9
• Molecular Formula: C17H17NO3
• Molecular Weight: 283.32
• Purity: ≥95%
• Synonyms: (E)-3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)prop-2-enamide
• InChI: InChI=1S/C17H17NO3/c19-15-8-6-14(12-16(15)20)7-9-17(21)18-11-10-13-4-2-1-3-5-13/h1-9,12,19-20H,10-11H2,(H,18,21)/b9-7+
• InChIKey: QOWABIXYAFJMQE-VQHVLOKHSA-N
• SMILES: C1=CC=C(C=C1)CCNC(=O)C=CC2=CC(=C(C=C2)O)O

KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2].
KS370G (1 mg/kg; oral; once daily for 8 weeks) improves left ventricular function and inhibited cardiac hypertrophy through the decrease of the phosphorylation of ERK, AKT and GSK3β in pressure-overload mice heart[1].
KS370G (10 mg/kg; oral; once daily for 13 days) attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice[2].

Reference

[1]. Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7.
 [Content Brief]

[2]. Weng YC, et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15.
 [Content Brief]

[3]. Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7.