For research use only. Not for therapeutic Use.
KSQ-4279 (USP1-IN-1) is a potent, first-in-class, and highly selective USP1 inhibitor. KSQ-4279 shows anticancer effects[1].
In BRCA1/2-mutated breast cancer cells, KSQ-4279 induces S-phase cell cycle arrest, marked accumulation of gamma-H2A histone family member X (ϒH2AX) and increases apoptosis[1].
KSQ-4279 shows dose-dependent, robust and durable anti-tumor regression in multiple TNBC and ovarian cancer Patient-derived xenografts (PDXs) with varied genomic status including BRCA1-mutated and -wildtype models[1].
| Catalog Number | I045127 |
| CAS Number | 2446480-97-1 |
| Synonyms | 6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine |
| Molecular Formula | C27H25F3N8O |
| Purity | ≥95% |
| InChI | InChI=1S/C27H25F3N8O/c1-15(2)37-13-20(27(28,29)30)35-24(37)18-6-4-16(5-7-18)12-38-25-19(11-34-38)10-31-23(36-25)21-22(17-8-9-17)32-14-33-26(21)39-3/h4-7,10-11,13-15,17H,8-9,12H2,1-3H3 |
| InChIKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |
| SMILES | CC(C)N1C=C(N=C1C2=CC=C(C=C2)CN3C4=NC(=NC=C4C=N3)C5=C(N=CN=C5OC)C6CC6)C(F)(F)F |
| Reference | [1]. Natalie Y L Ngoi, et al. Targeting the DNA damage response beyond poly(ADP-ribose) polymerase inhibitors: novel agents and rational combinations. Curr Opin Oncol. 2022 Sep 1;34(5):559-569. |
