For research use only. Not for therapeutic Use.
KT172 is a DAGLβ inhibitor with an IC50 value of 11 nM. KT172 can be used for the research of metabolic and inflammatory[1].
KT172 (0-100 μM) has DAGLβ inhibition activity with an IC50 value of 11 nM[1].
KT172 (2 µM) blocks probe-labeling of DAGLβ and ABHD6 activities[1].
KT172 (100 nM, 4 h) blocks DAGLβ activity in situ in the human prostate cancer cell line PC3 with high selectivity[1].
| Catalog Number | I012410 |
| CAS Number | 1402612-56-9 |
| Synonyms | (2-benzylpiperidin-1-yl)-[4-[4-(2-methoxyphenyl)phenyl]triazol-1-yl]methanone |
| Molecular Formula | C28H28N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H28N4O2/c1-34-27-13-6-5-12-25(27)22-14-16-23(17-15-22)26-20-32(30-29-26)28(33)31-18-8-7-11-24(31)19-21-9-3-2-4-10-21/h2-6,9-10,12-17,20,24H,7-8,11,18-19H2,1H3 |
| InChIKey | MXVVJNJNDCJCFS-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC=C1C2=CC=C(C=C2)C3=CN(N=N3)C(=O)N4CCCCC4CC5=CC=CC=C5 |
| Reference | [1]. Ku-Lung Hsu, et al. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol. 2012 Dec;8(12):999-1007. |
