For research use only. Not for therapeutic Use.
KT5720 (Cat.No:I007535) is a potent and selective inhibitor of protein kinase A (PKA). It competitively binds to the catalytic subunit of PKA, preventing its activation by cyclic adenosine monophosphate (cAMP). KT5720 is commonly used in research to study the role of PKA in various cellular processes, including signal transduction and gene expression.
| Catalog Number | I007535 |
| CAS Number | 108068-98-0 |
| Synonyms | KT 5720; KT5720; KT-5720.;hexyl (15R,16R,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8,10,12,20,22,24-nonaene-16-carboxylate |
| Molecular Formula | C₃₂H₃₁N₃O₅ |
| Purity | ≥95% |
| Target | PKA |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| InChI | InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36) |
| InChIKey | ZHEHVZXPFVXKEY-UHFFFAOYSA-N |
| SMILES | CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O |
| Reference | </br>1:In vitro and in vivo reversal of MDR1-mediated multidrug resistance by KT-5720: implications on hematological malignancies. Galski H, Sivan H, Lazarovici P, Nagler A.Leuk Res. 2006 Sep;30(9):1151-8. Epub 2006 Mar 20. PMID: 16542724 </br>2:KT-5720 reverses multidrug resistance in variant S49 mouse lymphoma cells transduced with the human MDR1 cDNA and in human multidrug-resistant carcinoma cells. Galski H, Lazarovici P, Gottesman MM, Murakata C, Matsuda Y, Hochman J.Eur J Cancer. 1995;31A(3):380-8. PMID: 7786606 |
