KT5823

• CAT Number: R014639
• CAS Number: 126643-37-6
• Molecular Formula: C₂₉H₂₅N₃O₅
• Molecular Weight: 495.53
• Purity: ≥95%
• Synonyms: [9S-(9α,10β,12α)]-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic Acid Methyl Ester; Antibiotic KT 5823; (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-metho
• Target: TGF-beta/Smad
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at -20 ℃
• IUPAC Name: methyl (15S,16R,18R)-16-methoxy-4,15-dimethyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate
• InChI: InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3
• InChIKey: QTYMDECKVKSGSM-UHFFFAOYSA-N
• SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC

KT5823 is a selective inhibitor of protein kinase G (PKG), a key regulator in various cellular processes, including smooth muscle relaxation, platelet aggregation, and neuronal signaling. By targeting the catalytic subunit of PKG, KT5823 suppresses its activity, providing valuable insights into PKG-mediated signaling pathways. This compound is commonly used in research related to vascular function, cellular signaling, and the modulation of smooth muscle tone. KT5823 serves as a crucial tool in studying PKG’s role in health and disease.