For research use only. Not for therapeutic Use.
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
| Catalog Number | R014639 |
| CAS Number | 126643-37-6 |
| Synonyms | [9S-(9α,10β,12α)]-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic Acid Methyl Ester; Antibiotic KT 5823; (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-metho |
| Molecular Formula | C₂₉H₂₅N₃O₅ |
| Purity | ≥95% |
| Target | Protein Kinase G |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Desiccate at -20C |
| InChI | InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3 |
| InChIKey | QTYMDECKVKSGSM-UHFFFAOYSA-N |
| SMILES | CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC |
| Reference | </br>1: Smolenski A, Burkhardt AM, Eigenthaler M, Butt E, Gambaryan S, Lohmann SM, Walter U. Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jul;358(1):134-9. Review. PubMed PMID: 9721015.</br></br> |
